Patient-Reported Outcomes: Knee Osteoarthritis
12-Month Follow-Up — Tracking pain, mobility, and quality of life improvements in KOA patients after WJ-MSC intra-articular injection.
42
Patients Enrolled
56 target knees treated
12 Months
Follow-Up Period
Assessments at 3, 6, 12 mo
↓55%
VAS Pain Reduction
6.2 → 2.8 at 12 months
↓49%
WOMAC Improvement
Total score reduction
Study Overview
This patient-reported outcomes study tracked 42 patients (56 target knees) who received a single intra-articular injection of 40×10⁶ Wharton's Jelly-derived mesenchymal stem cells for knee osteoarthritis. Patients were assessed at baseline, 3, 6, and 12 months using validated clinical instruments.
The cohort included Kellgren-Lawrence grades II–IV, with a median age of 61 years. All patients completed the full 12-month follow-up, and no serious adverse events were reported throughout the study period.
Pain Progression (VAS)
Visual Analog Scale scores (0–10) showing sustained pain reduction over 12 months.
Key Finding: 55% pain reduction sustained at 12 months — most improvement occurred within the first 3 months.
Functional Outcomes (WOMAC)
WOMAC index tracking pain, stiffness, and physical function over the 12-month follow-up.
| Time Point | Pain | Stiffness | Function | Total |
|---|---|---|---|---|
| Baseline | 12.8 | 4.6 | 38.2 | 55.6 |
| 3 Months | 8.4 | 3.2 | 27.5 | 39.1 |
| 6 Months | 7.1 | 2.8 | 22.8 | 32.7 |
| 12 Months | 6.2 | 2.4 | 19.6 | 28.2 |
Quality of Life (SF-12)
Physical and mental component scores tracked over 12 months (0–100, higher = better).
Physical Domain: +19.4 points (↑50%)
Mental Domain: +13.9 points (↑29%)
Conclusion
Patient-reported outcomes at 12 months demonstrate sustained and clinically meaningful improvements across all measured domains. Pain reduction of 55%, WOMAC total score improvement of 49%, and significant gains in both physical and mental quality of life confirm that WJ-MSC intra-articular injection provides durable benefits for knee osteoarthritis patients.
Individual results may vary. Read our full medical disclaimer.
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