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Differentiation

The process by which stem cells become specialised tissue cells such as bone, cartilage, muscle or nerve.

Stem cells growing in a laboratory culture flask, from a film explaining the treatment.

Mechanisms

What is Differentiation?

Differentiation is the biological process by which an unspecialised stem cell becomes a specialised cell type with a fixed function. Mesenchymal stem cells can differentiate into bone, cartilage, adipose, tendon and connective tissue under the right cytokine signals, while pluripotent and Muse cells have broader potential. In modern MSC therapy differentiation contributes only modestly to clinical benefit — most measurable improvement is driven by paracrine signaling and immunomodulation.

Related terms in Mechanisms

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